Thromboembolic Disease in Patients with Cancer:

First of all, we have to think about the risk of VTE in these patients. There are risk factors according to neoplasia, treatment ant patient. Risk factors related to neoplasia were lung (11/31), breast (4/31), colon (3/31) and 2 ovary and head/neck. Isolated cases of pancreas, stomach, sarcoma, prostate, peritoneum and unknown origin tumor were also described. According to tumor stage, more than 80% were metastatic disease. It is well known that stage IV is more prothrombotic than localized disease. Pathological anatomy is also important because adenocarcinoma is usually the most frequent one within VTE and cancer. So, 16/31 were adenocarcinomas, 5/31 epidermoids 2 serous and ductal, isolated cases of lobular, microcytic and non-small cell. In relation to treatment, the most important risk factor was chemotherapy, especially antiangiogenic (7/31). In addition, gemcitabine, platinum, etoposide, and irinotecan are the chemotherapy agents with the highest thromboembolic risk, indeed, in our sample 29/31 had received them [2]. Risk factors associated with the patient were non-oral contraceptives, recent surgery or the elderly population (12/31 were>65 years). 1/31 mutation carried the prothrombin gene. Comorbidities (Charlson Index) are also important. We reached a puntuation of 10 points; however 8 of 10 points were already for neoplasia and metastasis. Another factors to consider were previous admissions. So, 71% were admitted while 29% were ambulant (mostly Deep Venous Thrombosis).